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Raman Spectroscopy

Unlock Molecular Insights with Raman Spectroscopy. Our cutting-edge Raman analysis services provide non-destructive, specific, and versatile chemical analysis for your research and quality control needs. Explore the world of molecular composition and structure.

About Raman Spectroscopy


Welcome to the realm of advanced molecular analysis at HTL Biosolutions. Our Raman Spectroscopy services are meticulously tailored to meet the unique demands of the biotechnology sector, offering transformative insights and data-driven solutions. Raman spectroscopy is a powerful analytical technique used to study the structure of a sample. It works based on the Raman effect, which is the inelastic scattering of light when it interacts with matter.

The Raman spectrum of a protein and DNA contain information on both the secondary and tertiary structure of a protein and the helical forms of DNA. It is often used to study the protein structure, protein conformational changes, protein-protein and protein DNA interactions.  For a protein molecule, the stretching vibrations of the peptide C=O and C–N bonds and the aromatic side chains of Trp, Tyr, Phe have high Raman intensities. For a DNA, there are numerous discrete bands that can be used as a fingerprint of three-dimensional structure a DNA molecule. 

Applications of Raman Spectroscopy


Raman Spectroscopy empowers you to explore and understand the intricate world of biomolecules, including:

  1. Higher Order Structure: Gain profound insights into the higher-order structures of biomolecules and assess their stability, critical for ensuring product quality and efficacy. Both secondary and tertiary structure (fingerprint region)

  2. Comparability/Similarity Analysis: Confirm the comparability or similarity of biopharmaceutical products, including biosimilars, by analyzing their Raman spectra, ensuring consistency in structure and composition.

  3. Conformational Changes Under Stress or Formulation Conditions: Monitor conformational changes in biomolecules under varying conditions, providing insights into stability and potential aggregation.

  4. Protein Folding and Unfolding: Investigate the kinetics and thermodynamics of protein folding and unfolding, uncovering the mechanisms behind these vital processes.

  5. Protein-Ligand Interactions: Explore interactions between proteins and ligands, shedding light on binding mechanisms essential for drug discovery and development.

At HTL Biosolutions, we are committed to unlocking the full potential of Raman Spectroscopy for your biotechnology projects. Our team of experts, equipped with state-of-the-art technology and extensive knowledge, is here to ensure your success in every endeavor. We are not just service providers; we are your partners in molecular analysis.

Contact us today to harness the capabilities of Raman Spectroscopy and enhance your biotechnology projects.

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