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1.
1. Arakawa,
T., Ejima, D., Li,
T. and
Philo, J.S. The critical role of mobile phase composition in
size
exclusion chromatography of protein pharmaceuticals. J. Pharma. Sci., in press, 2009.
2.
Li, C.H. and Li,
T. Application
of Vibrational Spectroscopy to the Structural Analysis
of Human
Monoclonal Antibody Aggregates during Formulation
Development. Curr.
Pharma. Biotech.
10,
391-399, 2009.
3.
Chelius, D., Jing, K., Lueras, A.M.K., Rehder,
D., Dillon, T.M., Vizel, A., Rajan, S. R., Li, T.,
Treuheit, M. and Bondaernko, P.V.
Formation of Pyroglutamic Acid from N-Terminal
Glutamic
Acid in Immunoglobulin g
Antibodies.
Anal. Chem.
78(7); 2370-2376,
2006.
4.
Rajan, R.S., Li, T., Aras, M., Sloey,
C., Sutherland, W., Arai, H., Briddell, R.,
Kinstler, O., Lueras,
A. M.K., Zhang,
Y., Yeghnazar, H., Treuheit, M. and Brems, D.N.
Modulation of protein
aggregation by polyethylene glycol conjugation: GCSF as a case study.
Prot. Sci.
15, 1063-1075,
2006.
5.
Li, T.
Investigation of Protein-Protein Interactions
by Isotope Edited Fourier Transformed
Infrared Spectroscopy.
Spectroscopy, 18, 397-406, 2004.
6.
French, D., Arakawa, T. and Li, T.
FTIR Spectroscopic Investigation of Protein
Conformation in
Spray-Dried Protein-Trehalose Powders.
Biopolymers,
73(4 ), 524-531, 2004.
7. Kerwin,
B.A., Chang, B.S., Gegg, C.V., Gonelli, M., Li, T. and Strambini, G.
Interactions between
PEG and
type I soluble tumor necrosis factor receptor:
Modulation by pH and by PEGylation at
the N
terminus. Protein Science. 11(7), 1825-1833,
2002.
8. Li,
T.,
Talvenheimo, J., Zeni, L., Rosenfield, R., Stearns, G.
and Arakawa, T. Changes
in Protein
Conformation and Dynamics upon BDNF/trkB Complex
Formation: An Investigation by Isotope-
Edited
FTIR Spectroscopy.
Biopolymers, 67(1), 10-19, 2002.
9. Li,
T.,
Yamane, H., Arakawa, T., Narhi, L.O. and Philo, J.
The Effect of the Intermolecular
Disulfide
Bond on the Conformation and Stability of Glial Cell
Line-Derived Neurotrophic
Factor.
Prot.
Eng., 15(1), 59-64, 2002.
10. Li,
T.,
Narhi, L.O., Wen, J., Philo, J.S., Sitney, K., Inoue,
J.-I., Yamamoto, T. and Arakawa, T.
Interactions
between NFkB and Its Inhibitor ikB:
Biophysical Characterization of an NFkB/ikB
Complex.
J. Prot. Chem. 17(8),
757-763, 1998.
11. Li,
T.,
Horan, T., Osslund, T., Stearns, G. and Arakawa, T.
Conformational Changes in
G-CSF/Receptor
Complex As Investigated by Isotope-Edited FT-IR
Spectroscopy.
Biochemistry,
36, 8849-8857, 1997.
12. Eich, R.F., Li,
T., Lemon, D.D., Doherty, D.H., Curry, S.R.,
Aitken, J.F., Mathews, A.J., Johnson,
K.A., Smith, R.D., Phillips, G.N., Jr. and Olson,
J.S. Mechanism
of NO-Induced Oxidation of
Myoglobin and Hemoglobin.
Biochemistry
35, 6976-6983, 1996.
13. Quillin, M., Li,
T., Olson, J.S., Phillips, G.N., Jr., Dou, Y.,
Ikeda-Saito, M., Rega_n, R., Carlson, M.,
Gibson, Q.H., Li, H. and Elber, R. Structural and Functional Effects of Apolar Mutations of
the
Distal Valine in Myoglobin.
J. Mol.
Biol., 245, 416-436 (1995).
14.
Li, T.,
Quillin, M., Phillips, G.N. and Olson, J.S.,
Structural Determinant of CO Stretching
Vibrations in Myoglobins, Biochemistry,
33,
1433-1446 (1994).
15. Li,
T.,
Johnson, J.E. and Thomas, G.J., Jr., Raman Dynamic
Probe of Hydrogen Exchange in
Bean
Pod Mottle Virus:
Base-Specific Retardation of Exchange in
Packaged ssRNA.
Biophysical
J., 65,
1963-1972 (1994).
16. Li,
T.,
Bamford, J.K.H., Bamford, D.H. and Thomas, G.J., Jr.,
Structural Studies of the Eveloped
dsRNA
Bacteriophage ø6 of Pseudomonas
syringae by Raman Spectroscopy.
I. The
Virion
and
Its Membrane, J.
Mol. Biol., 230, 461-472
(1993).
2
17. Bamford, J.K.H., Bamford, D.H., Li, T. and Thomas, G.J., Jr., Structural Studies of the Eveloped
dsRNA Bacteriophage ø6 of Pseudomonas
syringae by Raman Spectroscopy.
II. Nucleocapsid
Structure and Thermostability of Virion, Nucleopsid
and Polymerase Complex, J.
Mol. Biol., 230,
473-482 (1993).
18. Li,
T.,
Chen, Z., Johnson, J.E. and Thomas, G.J., Jr.,
Conformations, Interactions, and
Thermostabilities
of RNA and Proteins in Bean Pod Mottle Virus:
Investigation of Solution and
Crystal
Structures by Laser Raman Spectroscopy, Biochemistry, 31,
6673-6682 (1992).
19.
Li,
T.,
Chen, Z., Johnson, J.E. and Thomas, G.J., Jr.,
Structural Studies of Bean Pod Mottle Virus,
Capsid and RNA in Solution and Crystal States by Laser
Raman Spectroscopy, Biochemistry,
29,
5018-5026 (1990).
Published Patents
1. Li,
T., Chang, B., Sloey, C.
L-Methionine As A Stabilizer for NESP/EPO in
HSA-Free
Formulations. Filled
in 2001, Application# 20030104996, published in 2003.
WO/2003/020299;
International
Application No.: PCT/US2002/027855.
2.
Goldenberg, M., Zhang, D., Beekman, A., Li, T. Polyol/Oil
Suspensions for the Sustained
Release of Proteins. Patent# 6,979,674, 2005.
3.
Li, T. and Sloey, C.
Stable
aqueous protein or antibody pharmaceutical formulations
and their
preparation.
Filed in 2006.
USPTO
Applicaton #: 20070053871, WO/2007/037795.
4. Li,
T., Ko, J.
and Sloey, C. Stable
aqueous protein formulations.
Filed in 2007.
United States
Patent# 20070053871.
5. Li,
T., Rajan, R., Lueras, A., Huang, H., Chu, G.
Compositions of specific binding agents
to
hepatocyte growth factor.
Filed in 2007.
USPTO
Applicaton #: 20090042315.
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