At HTL Biosolutions, Inc., we provide analytical services on a full range of HPLC analysis of proteins, including size-exclusion (SEC), ion-exchange (IEX), hydrophobic interaction (HIC) and reversed-phase (RP) HPLC chromatography.  We also provide peptide-mapping service according to customer's specific request. 

Key Benefits

• Analysis of protein aggregates
• Analysis of protein degradants such as clip, cyclization and fragmentation
• Analysis of chemical modification of proteins such as oxidation, deamindation

Capabilities

Size-exclusion chromatography (SEC-HPLC)

This technique is often used to provide quantitative analysis of protein aggregates and clips.

Ion-exchange chromatography (IEX)

Anion-exchange to characterize protein charge isoforms, and deamindated species.

          Cation-exchange to characterize protein charge isoforms, and deamindated species.

Reversed-phase chromatography (RP-HPLC)

Quantitative analysis of protein degradants such as oxidation, deamindation and clips.

Hydrophobic interaction chromatography (HIC)

Analysis of protein variants under non-denaturing condition.

Peptide Mapping

Determination of degradations occurring at specific amino acid positions.